脂联素调控脂质代谢的研究进展

doi:10.11843/j.issn.0366-6964.2018.12.003

Abstract

Abstract:

Adiponectin (AdipoQ) is an adipocytokine mainly secreted by adipose tissue. Recent studies have shown that adiponectin played an important role in regulating lipid metabolism in animals. Adiponectin firstly binds to C terminal of adiponectin receptors, namely AdipoR1 and AdipoR2, N terminal of adiponectin receptor is combined with signal adapter protein (APPL1 and CK2) subsequently, then affect the activity or expression of related kinases (LKB1 and SIRT1), finally activate AMPK and PPARα signaling factors to promote fatty acid oxidation and inhibit lipid synthesis, thereby exerting lipid-lowering effects. At present, the research on lipid metabolism regulated by adiponectin have focused on human and rodents, and some progress has been made in the study of related molecular regulation mechanisms. This article reviews the discovery, structure, tissue distribution, signal adapter proteins of adiponectin, as well as the mechanism of adiponectin regulating animal lipid metabolism in order to provide a partial reference for further exploring the role of this gene in the regulation of lipid metabolism.

CLC Number:

S811.3

TANG Ni, WANG Shu-yao, QI Jin-wen, WU Yuan-bing, LI Zhi-qiong. Research Progress on Adiponectin Regulating Lipid Metabolism[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(12): 2550-2557.

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Research Progress on Adiponectin Regulating Lipid Metabolism

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